Higher body temperature may increase risk of autoinflammatory disorder

Higher body temperature may increase risk of autoinflammatory disorder

If your children develop an autoinflammatory disease, you should carefully consider their core body temperature. autoinflammatory disease it is a rare syndrome that is mostly unknown, even by those who suffer from it, causing a lack of understanding by family or friends. Severe symptoms can be life-threatening. Therefore, we must pay close attention to children with periodic fever because it is not just a fever.

Elevated temperature is likely to be a trigger for inflammatory flare-ups

A recent study from the Garvan Institute for Medical Research has shown that core body temperature may be associated with mevalonate kinase deficiency (MKD). If body temperature rises, it can trigger inflammatory flares in patients with this rare autoinflammatory disease.

MKD is an inborn error of metabolism caused by two copies of a mutant gene from each parent. This recessive disorder has mutations in the genes for mevalonate kinase (an enzyme present in all cells of the body). The deficiency of this enzyme leads to the accumulation of defective proteins in the immune cells, which triggers inflammation. The study is published in Clinical Research Journal.

The disorder usually occurs in early childhood with regular symptoms such as high fever, skin rash, ulcers, swollen lymph nodes, and abdominal pain.

Poorly understood mechanisms of inflammatory flare-ups

Due to the infrequent of autoinflammatory disease, many people, including medical professionals, do not pay much attention to the disorder and therefore do not have a complete understanding of the condition.

“There has been very little progress in understanding MKD and, in particular, what causes disease flares in MKD patients. One of the main reasons for this lack of knowledge is the absence of appropriate animal models to study the mechanisms of the disease”, says Dr. Marcia Muñoz de Garvan, lead author of the study.

Setting up the experiment, the researchers modified the gene in mouse models that precisely mimic the mutations in MKD patients.

Muñoz revealed that an increase in core body temperature exacerbated the impact of the mutant enzymes and led to the accumulation of abnormal proteins, a likely cause of the inflammatory flare-ups in the patients.

According to Professor Mike Rogers, head of the bone therapy laboratory at Garvan, “The disease is caused by having two copies of the mutant gene and there are more than 250 known mutations, so it is difficult to predict which combination causes mild or severe disease.” . MKD version.”

This is why MKD has a wide range of disease severity and is poorly understood.

Certain levels of enzyme activity have an effect on proteins

To gain insight into the mechanism of this disorder, the researchers developed different combinations of mutants in models with enzyme activity (mevalonate kinase) at 10 to 20 percent of normal levels. They found that there is no disease at the 20 percent level or higher. However, something happened when the level fell below this threshold.

“The disease starts to appear if the enzyme activity falls below this threshold, when the effect on the proteins really kicks in,” says Rogers.

Animals with 10 percent activity experienced clear signs of disease and higher levels of abnormal or defective proteins. Mainly, the elevated temperatures decreased enzyme activity to almost undetectable levels, increasing the amounts of abnormal proteins.

These findings can help predict the severity of disease symptoms, such as measuring the level of abnormal proteins in blood samples. Doctors can also use this information to diagnose and manage the disease, according to Rogers.

In addition, the researchers also found that the NLRP3 protein, involved in many inflammatory disorders in general, plays a role in the inflammatory process of MKD. The researchers are interested in discovering new treatments for MKD by targeting this protein and hopefully developing NLRP3 blockers for clinical use.

“Our research provides exciting new insights into the underlying physiology of MKD and what can trigger inflammatory flare-ups, opening up potential new ways to treat this devastating disorder,” says Rogers.

How to Lower Core Body Temperature Naturally

Parents whose children have experienced periodic fever should check their body temperature regularly. There are medically verified methods and home remedies that experts have suggested to lower your core body temperature naturally and safely.

  • Drink cool liquidDrinking cold liquids is a good way to lower your body temperature. An adequate amount of water can prevent dehydration, but sugary drinks and popsicles can lead to further dehydration. Furthermore, coconut water has an innate cooling effect.
  • Relax in a fresh air environment.—Experts recommend that air conditioning help prevent heat stroke and heat-related deaths. Sitting in front of a fan is also a good way to cool down your body.
  • Take medicine to lower the fever:Antipyretic (temperature-reducing) medications are safe and effective in lowering body heat. Children with autoinflammatory diseases should follow their doctor’s instructions before taking medications.
  • Avoid extreme or strenuous activities:Our body will heat up during hot or humid conditions, so a high intensity level of training will increase our body temperature. Try to do moderate-intensity exercise, such as walking and cycling, but be sure to take frequent breaks. Swimming can be a good way to exercise and soak in cool water at the same time.
  • Dress in light colors and loose clothing to reduce heat retention—Light colors reflect sunlight rather than absorb it, thus preventing the body from overheating. Oversized clothing helps air circulate over your skin and cool your body, but be sure to cover your skin from sun exposure.
  • Avoid spicy and fatty foods—Body temperature can rise quickly with hot and spicy foods because they increase metabolism and stimulate body heat. The consumption of fatty foods increases the fat stored in the cells of the body, thus trapping heat and making the body more heated.
  • Take a warm bath—Warm water helps lower body temperature as the water evaporates. When you are not showering, placing cool cloths on the forehead and back of the neck can also help reduce temperature. On the other hand, cold showers or ice baths They are also recommended for rapidly cooling the skin, especially when an individual is at risk of heat stroke.

Other than that, have a hydrating dietEating fruits and vegetables rich in vitamin C or applying aloe vera gel to the skin can also help balance body temperature. These are remedies that help change the patient’s lifestyle in a more positive way to deal with KD and autoinflammatory disease in general.

Trinh Dinh

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