Hormone’s vital role discovered: Could predict men’s long-term health

Hormone’s vital role discovered: Could predict men’s long-term health
Energy Vitality Human Health Longevity

Scientists have found that the level of a new insulin-like peptide hormone, called INSL3, in the blood correlates with a variety of age-related diseases, including weak bones, sexual dysfunction, diabetes, and cardiovascular disease.

Scientists have discovered the vital role of a hormone, which develops in men during puberty, in providing an early prediction of whether they might develop certain diseases later in life.

Researchers at the University of Nottingham have found that a new insulin-like peptide hormone, called INSL3, is consistent over long periods of time and is an important early biomarker for predicting age-related disease. Their latest findings will be published today (November 8) in the journal Frontiers in Endocrinology.

INSL3 is produced by the same cells in the testicles that produce testosterone, but unlike testosterone which fluctuates throughout a man’s life, INSL3 remains constant, with the level at puberty roughly the same throughout life. life of a man, decreasing only slightly in old age. This makes it the first clear and reliable predictive biomarker of age-related morbidity compared to any other measurable parameter.

The results show that the level of INSL3 in the blood correlates with a number of age-related diseases, including weak bones, sexual dysfunction, diabetes, and cardiovascular disease.

The discovery of the constant nature of this hormone is very important as it means that a man with a high INSL3 when he is young will continue to have a high INSL3 when he is older. But someone who already has a low INSL3 at a young age will have a low INSL3 when he is older, making him more prone to typical age-related diseases. This opens up exciting possibilities for predicting age-related diseases and finding ways to prevent the onset of these diseases with early intervention.

The research was led by Professor Ravinder Anand-Ivell and Professor Richard Ivell and is the latest of three recent studies* on this hormone. Professor Ravinder Anand-Ivell explains: “The holy grail of aging research is to reduce the fitness gap that appears as people age. Understanding why some people are more likely to develop disabilities and illnesses as they age is vital so that interventions can be found to ensure that people not only live long but also healthy lives as they age. Our discovery of hormones is an important step in understanding this and will pave the way not only to help people individually, but also to help alleviate the care crisis we face as a society.”

The team analyzed blood samples from 3,000 men from 8 regional centers in northern, southern, eastern and western Europe, including the UK, with two samples taken four years apart. The results showed that, unlike testosterone, INSL3 remains at constant levels in people

The study also showed that the normal male population, even when young and relatively healthy, still shows a wide variation between individuals in the concentration of INSL3 in the blood, almost 10-fold.

Professor Richard Ivell adds: “Now that we know the important role this hormone plays in predicting disease and how it varies between men, we are turning our attention to finding out which factors have the greatest influence on the level of INSL3 in the blood. Preliminary work suggests that nutrition in early life may play a role, but many other factors, such as genetics or exposure to some environmental endocrine disruptors, may play a role.”

Reference: “The Lydia Cell Biomarker INSL3 as a Predictor of Age-Related Morbidity: Findings from the EMAS Cohort” Nov 8, 2022, Frontiers in Endocrinology.
DOI: 10.3389/fendo.2022.1016107

Leave a Comment