Psilocybin: hallucinogen in ‘magic mushrooms’ could pave way for treatment of severe depression

Psilocybin: hallucinogen in ‘magic mushrooms’ could pave way for treatment of severe depression

Magic mushrooms or psilocybin mushrooms have come a long way when it comes to large ongoing trials for the treatment of major depression. Now, a new study published this week suggests magic mushroom approval is nearing, indicating that a single dose of psilocybin is already possible for a treatment-resistant episode of major depression.

Depression or major depressive disorder is known as a common but serious mental ailment, which negatively affects people’s mood, emotion, thinking and even motivation in life. For years, scientists have been experimenting with “magic mushrooms” containing the hallucinogen psilocybin to mitigate or cure medical illness, as well as its more dangerous condition called severe depression.

Magic Mushroom Developments


(Photo: Photo by GUILLAUME SOUVANT/AFP via Getty Images)

With these attempts comes long-standing evidence that magic mushrooms can potentially serve as a treatment for depression. Clinical trials on the ‘magic mushroom’ have already started in recent years, which were also covered by Nature World News. During this period, promising results were shown by the progress of theoretical knowledge and practical applications of these hallucinogenic mushrooms.

The findings and update on the large ongoing trial of magic mushrooms for the treatment of severe depression were published in the journal. The New England Journal of Medicine on Thursday November. Lead author Dr. Guy Goodwin, medical director of Compass Pathways, stated that the trial is currently in Phase 3 in consultation with the Food and Drug Administration (FDA) for approval.

The current phase is examining psilocybin for use in treatment-resistant depression. The results showed that depression scores were reduced by more than 1 milligram dose for the participants over a period of more than three weeks. A total of 79 participants with treatment-resistant depression joined the study.

Also read: This Mushroom Could ‘Magically’ Cure Depression With No Side Effects

What is depression?

According to the American Psychiatric Association (APA)Symptoms of depression can range from mild to severe and may include the following emotional or physiological signs:

  • sad or depressed mood
  • loss of interest in activities
  • extreme weight gain or loss
  • sleeping too much or lack of sleep
  • increased fatigue
  • thoughts of death or suicide

The APA states that symptoms of depression must last for at least two weeks and show a significant change from the previous level of functioning for a diagnosis of depression to occur. Also, medical conditions like thyroid problem, brain tumor, or vitamin deficiency can mimic or mimic the symptoms of depression.

In addition, there are also cases where bipolar disorder or bipolar illness causes a person to experience mood swings with emotional highs and lows (mania or hypomania) and emotional lows (depression). according to Mayo Clinic.

Antidepressant Mushroom Test

Several reports have interpreted recent advances in the study to prove that the mushroom drug psilocybin can treat depression; in which a single treatment of the synthetic magic mushroom contains the hallucinogen, which is a mind-altering ingredient.

Reports highlighted improvement in depression in people affected by a treatment-resistant form of the disease. Experts in the field have reportedly found the new research and its findings promising.

Scientists involved in the research found a dose effect and clinically significant improvement in just three weeks, according to Dr. Matthew Johnson, a professor at Johns Hopkins Medicine, who was not involved in the new study, as cited by CNN.

Related article: Magic Mushroom Compound May Be Future Treatment for Depression

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