Vitamin D Linked to Reduced Mortality in Osteoarthritis Patients

Vitamin D Linked to Reduced Mortality in Osteoarthritis Patients

The well-established roles of vitamin D in bone calcium metabolism make vitamin D a highly influential factor that can be used for the prevention and treatment of the common musculoskeletal disorder osteoarthritis (OA).

In addition, vitamin D has been shown to have benefits in many non-skeletal diseasessuch as cardiovascular disease (CVD), diabetes and cancer, through its effects of reducing inflammation, antiproliferative activity, antioxidant activity, etc.

Although the benefit of vitamin D in reducing mortality has been reported in the general population and in diabetic patients, only a few studies have focused on such a relationship for OA patients.

Therefore, the present study aimed to assess whether serum 25(OH)D concentrations were associated with all-cause and cause-specific mortality in OA patients from NHANES III (National Health and Nutrition Examination Survey). in the US) and the newly published NHANES 2001–2018 database.

This study concludes that OA patients with sufficient serum 25(OH)D were associated with a significantly lower risk of all-cause mortality and CVD than those with lower 25(OH)D levels, suggesting a beneficial role. of vitamin D in the long term. -basic term.

“Furthermore, relatively lower hazard ratios (HRs) were observed in men than in women, highlighting the need to develop gender-specific therapeutic strategies for patients with OA, especially postmenopausal women.” says the report.


In this analysis, 4570 patients with OA were included, with a median follow-up of 7.6 years. Approximately 65.53% of the patients were women and the mean age was 61.82 ± 12.94 years.

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