Advertisement of the effect of ginseng and red ginseng to improve memory and suppress bone and muscle loss

Advertisement of the effect of ginseng and red ginseng to improve memory and suppress bone and muscle loss

Seoul, South Korea, November 3, 2022 /PRNewswire/ — Experts who have conducted scientific studies on the effect of ginseng gathered at seoul of all the world. The Korean Ginseng Society (chaired by read man-hui) said that the 13the International Symposium on Ginseng was held from 25the to 28the at Lotte Hotel Seoul.

The 13th International Symposium on Ginseng 2022.

The 13th International Symposium on Ginseng 2022.

Professor Seikwan Oh’s team at Ehwa Womans University School of Medicine finds that red ginseng improves memory loss and learning ability

According to the findings of a 2022 research study, red ginseng improves memory loss associated with post-traumatic stress disorder (PTSD)[1]

Post-traumatic stress disorder is a stress-induced memory impairment that accompanies neuroinflammation. Professor Seikwan Oh’s team (Joint Investigator: Bombi Lee of Kyunghee University School of Oriental Medicine) performed a passive avoidance test and a Morris water maze test on 48 six- to eight-week-old rats (rats). experiments), divided into six groups, to check their learning abilities and spatial cognition after giving a one-time constant stress and injecting red ginseng extract 20, 50, 100 mg/kg/1 day for 14 days. The results showed that the stressed rats were delayed in escaping the maze, while the red ginseng-injected group escaped the maze at a similar speed to the unstressed group. They also checked the levels of various stress-induced inflammatory cytokines. Red ginseng appeared to reduce interleukin-6 (IL-6) and interleukin-8 (IL-8), which are markers of stress-induced inflammation, while it increased interleukin-12 (IL-12), which is the anti-inflammatory marker that suppresses inflammation. Furthermore, the group injected with red ginseng did not show an increase in NF-kB, which increased and caused inflammation in the hippocampus of the stressed group, and the generation of mRNA, which is the growth factor of impaired cranial nerves, recovered in 252.51%. after red ginseng injection (p < 0.05).

The team also revealed the effect of red ginseng on age-related memory decline (2015). They injected red ginseng extract (approx. 200/kg/1 day) into 32 18-month-old mice divided into four groups for three months after inducing cognitive decline, and then performed the Y-maze test to assess the effect on cognitive impairment. space. cognitive ability and the Morris water maze test to assess spatial cognition and learning abilities. The result showed that red ginseng suppresses age-related learning and memory failure. The findings verified the antidementia effect using elderly experimental animals that had memory lapses amid a continuing rise in dementia among the elderly.

Professor Hyong Young Kwon Soonchunhyang University team verifies that ginseng (ginsenoside Rd) suppresses muscle loss

Published in the Journal of Cachexia, Sarcopenia and Muscle (JCSM)[2] with IF of 12.91 (as of 2022)

Professor Hyong Young Kwon The Soonchunhyang University team said they verified the impact of Rd ginsenoside on muscle cells and the effect of strengthening muscles, and identified the mechanism of action. The findings were published in the Journal of Cachexia, Sarcopenia and Muscle, 2022, which has an impact factor (IF) of 12.91. The FI is an index figure used to compare and assess the relative importance of journals. Research published in a journal of IF 10 or higher is considered highly reliable.

Muscle atrophy is a general degenerative disease that is caused by muscle loss and hypofunction, and can cause various cardiovascular diseases, cancers, blood poisoning, obesity, and depression. According to the results of Professor’s research Hyong Young Kwon team, the muscle strength of aged mice injected with ginsenoside Rd improved over time to a level similar to that of adult mice overall. In addition, their C2C12 muscle cell grew larger than the control group, and the number of nuclei per cell increased from 20% to 37% over six nuclei.

Such effects also appeared in muscle atrophy caused by steroid administration. The team also identified the mechanism by which ginsenoside Rd increases muscle cell size by reducing active oxygen within muscle cells increased by TNF-α, the gene that induces inflammation. Ginsenoside Rd increased muscle cell size and induced cell fusion by activating pAKT, which is the essential pathway for muscle cell protein synthesis, and reducing MuRF1, which promotes proteolysis.

Furthermore, they implicated that ginsenoside Rd can be used to prevent and treat muscle atrophy caused by cancer cachexia by showing that it reduces phosphorylation, atrogin-1, and MuRF-1* that cause inflammation and induce TNF-activated muscle wasting. -α and interferon. -gamma (IFNg), which causes inflammation when cancer cells grow or spread. Such an effect of ginsenoside Rd in suppressing muscle loss also appeared in a cell test using human skeletal muscle (HSkM) cells, as well as in animal cells.

Professor Narayanan’s team from University of Michigan verifies that red ginseng prevents bone loss by maintaining a balance in intestinal microorganisms[3]

The gut microbiota is an important driver for bone health. Intestinal microorganisms that are unbalanced or reduced in variety and number by extensive antibiotic treatment can cause bone loss, and bones are known to be healthy when intestinal microorganisms vary in types.

The professor’s team injected a broad-spectrum antibiotic into 21 adult male mice divided into four groups for two weeks, and then, for four weeks, injected water into one group and red ginseng extract 500 mg/kg/1 day into another group . As a result, the variety of intestinal microorganisms of the mice decreased significantly after antibiotic injection, but was significantly suppressed in the red ginseng-injected group, along with the suppression of barrier damage. In addition, considerable bone loss occurred in the femur and spine of the mice, but this was prevented in the red ginseng-injected group.

Professor Vuksan’s team from Canada verifies that ginseng improves blood pressure in patients with high blood pressure and diabetes, and is safe for consumption by patients[4]

Professor Vuksan’s team from Canada conducted a clinical trial on 80 patients with type 2 diabetes and high blood pressure for 12 weeks, and found that central systolic blood pressure was significantly reduced in the group given Korean red ginseng and American ginseng in parallel after 12 weeks ( reduction of 3.98±2 mmHg, p=0.04). Above this, there were no significant changes in pulse wave velocity and reactive hyperemia index, which are used to assess blood vessel function. Consequently, he confirmed that ginseng can improve the central systolic blood pressure of diabetic patients when given as an adjunct, in addition to medication, without directly affecting blood vessel function.

Also, teacher seo sang-Hee’s team from Chungnam University presented that ginseng improves immunity against COVID 19 infection and improves immunity over time. Researchers from other countries also revealed their research results on various effects of ginseng and red ginseng. like the teacher Tianshi Wang Shanghai Jiao Tong University team, Porcelain. They revealed the effect of Rh1 ginsenoside, one of the active ingredients of red ginseng, in suppressing the risk of breast cancer metastasis. Professor Narayanan’s team from University of Michigan, USA showed that red ginseng maintains the balance of intestinal microorganisms, suppresses barrier damage and prevents bone loss. In addition, Professor SM Kamruzzaman’s team said in particular that they found that red ginseng suppressed the generation of blood clots and the activation of alkaline phosphatase (ALP) which causes liver inflammation when exposed to arsenic, aspartate transaminase (AST), the liver enzyme representing liver damage and alanine aminotransferase (ALT).

[Reference] * STAT3, atrogin-1, MuRF-1 phosphorylation

STAT3 (signal transducer and activator of transcription-3), atrogin-1, and MuRF-1 (muscle ring finger = 1) are proteins that promote the generation of various genes within cells, and atrogin-1 and MuRF- 1 are especially involved in fusion and differentiation of muscle cells.

[1] Seikwan Oh, Bombi Lee, Bongjun Sur, Neuroprotective effect of Korean red ginseng against prolonged stress-induced memory impairments and inflammation in rat brain associated with BDNF expression, Journal of Ginseng Research 46 (2022) 435 -443
[2] Hyog Young Kwon, Yoseph Toni Wijaya et al., Ginsenoside Rd improves muscle wasting by suppressing signal transducer and activator of transcriptional pathway 3, Journal of Cachexia, Sarcopenia and Muscle 2022 DOI: 10.1002/jcsm.13084
[3] Narayanan Parameswaran, HJ Kang, N. Chargo, S. Chennupati et al., Treatment with Korean red ginseng extract prevents post-antibiotic dysbiosis-induced bone loss in mice, Journal of Ginseng Research, https://doi .org/10.1016/j.jgr.2022.08.006
[4] Vladimir Vuksan, Elena Jovanovski, et al., Vascular effects of combined administration of enriched Korean red ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolius) in people with hypertension and type 2 diabetes: a randomized controlled trial, Complementary Therapies in Medicine 49 (2020) 102338

SOURCE The Korean Ginseng Society

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