Covid study of unvaccinated samples puts cutting-edge research on the map

Covid study of unvaccinated samples puts cutting-edge research on the map

Oak Crest Institute of Science unexpected findings seen as a new tool to manage patient care and optimization of tests

MONROVIA, Calif., October 27, 2022 /PRNewswire/ — Waging the fight against COVID-19 from the front lines, the Oak Crest Institute of Science has released groundbreaking findings with important medical and public health implications.

“We measured the rate at which SARS-CoV-2 reproduces in unvaccinated people at various times, from when they were first infected until there was no longer any detectable virus present in their bodies. We also measured changes in their response immune system,” said the executive director. Marc M Baum said.

“Our findings can be used to develop guidelines for the clinical management of COVID-19 patients and optimize testing procedures to determine whether people are infected with SARS-CoV-2.”

Link to full abstract in Communications Medicine: https://www.nature.com/articles/s43856-022-00195-4

Oak Crest is a nonprofit research institute in southeastern california who developed an FDA-approved reaction test to detect the virus in nasal swabs. That led to the selection of Oak Crest as an Institutional Review Board-approved clinical study site. All Oak Crest researchers participated. https://www.oak-crest.org/faculty-and-staff/

Nine study participants who developed COVID-19 between November 2020 Y March 2021 They were monitored for three months. Blood samples were evaluated for viral loads as well as antibody responses and associated inflammatory biomarkers.

The results yielded some unexpected findings:

  • Early viral replication is rapid, with a mean doubling time of 3.1 hours, providing a narrow window between exposure and viral shedding (w(when the virus can be spread by sneezing, coughing or talking).

  • The clearance phase is slow and heterogeneous.

  • Host immune responses differ widely among participants.

“The results of our small study provide a rare insight into the life cycle of COVID-19 infection and have a number of important biological, clinical, and public health implications,” Baum said.

Oak Crest also conducted research on HIV prevention, the delivery and sustained release of HIV drugs, and the development of new drug candidates for the delivery, prevention, and treatment of infectious diseases. Research into HIV prevention and the development of sustained delivery devices to be used for HIV prevention will continue, and new developments are expected.

ABOUT OAK CREST INSTITUTE OF SCIENCE
https://www.oak-crest.org/
Oak Crest Institute of Science (Oak Crest) is a 501(c)(3) nonprofit organization with a mission to facilitate high-quality, productive research opportunities in fundamental chemistry and environmental science for students at all academic levels. . Oak Crest was established specifically to teach and conduct cutting-edge scientific research. The institute provides an experiential role in education, where students work on authentic, funded research projects and develop a sense of belonging to the STEM community. Since its founding in 1998, Oak Crest has been involved in educational programs, forming groups to experience guided research and peer mentoring. In 2006, the Oak Crest Institute of Science received an NSF Undergraduate Research Experiences site grant, the first to focus on community college students. Oak Crest provides more than 100 students annually with the opportunity to perform hands-on laboratory experiments. The Institute
We also offer tours and workshops to more than 1,000 students, teachers and the general public.

Media Contact:
Paul Webster, Doctor. higher faculty
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SOURCE Oak Crest Institute of Science

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